Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells
K Lieb, S Engels, BL Fiebich - Neurochemistry international, 2003 - Elsevier
Nitric oxide (NO) has been implicated in the etiopathology of multiple sclerosis (MS) and its
animal model, experimental autoimmune encephalomyelitis (EAE), and inhibition of NO
synthesis has been proposed to be a possible mechanism of action of drugs to treat MS. In
the present study, we investigated the inhibitory effect on NO synthesis of various steroids,
cytokines and drugs used or proposed for the treatment of MS. As a model system, we used
primary rat microglial cells which produce NO synthase and subsequently release NO upon …
animal model, experimental autoimmune encephalomyelitis (EAE), and inhibition of NO
synthesis has been proposed to be a possible mechanism of action of drugs to treat MS. In
the present study, we investigated the inhibitory effect on NO synthesis of various steroids,
cytokines and drugs used or proposed for the treatment of MS. As a model system, we used
primary rat microglial cells which produce NO synthase and subsequently release NO upon …