[HTML][HTML] Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin
Altered cellular adhesion and apoptotic signaling in cardiac remodeling requires
coordinated regulation of multiple constituent proteins that comprise cytoskeletal focal
adhesions. One such protein activated by cardiac remodeling is related adhesion focal
tyrosine kinase (RAFTK, also known as pyk2). Adenoviral-mediated expression of RAFTK in
neonatal rat cardiomyocytes involves concurrent increases in phosphorylation of Src, c-Jun
N-terminal kinase, and p38 leading to characteristic apoptotic changes including cleavage …
coordinated regulation of multiple constituent proteins that comprise cytoskeletal focal
adhesions. One such protein activated by cardiac remodeling is related adhesion focal
tyrosine kinase (RAFTK, also known as pyk2). Adenoviral-mediated expression of RAFTK in
neonatal rat cardiomyocytes involves concurrent increases in phosphorylation of Src, c-Jun
N-terminal kinase, and p38 leading to characteristic apoptotic changes including cleavage …