Natriuretic peptides inhibit apoptosis and prolong the survival of serum-deprived PC12 cells
RR Fiscus, AWK Tu, SBC Chew - Neuroreport, 2001 - journals.lww.com
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were investigated to
determine effects on apoptotic DNA fragmentation and survival in serum-deprived PC12
cells. Both peptides caused prolonged cGMP (but not cAMP) elevations lasting for≥ 6 h.
The cGMP elevations were 10-, 50-and 68-fold for ANP and 26-, 100-and 148-fold for BNP
at 1, 10 and 100 nM, respectively. BNP caused dose-dependent increases in cell survival
rates during 3 days of serum deprivation. BNP (1 nM) increased 24 h survival rate from 36 …
determine effects on apoptotic DNA fragmentation and survival in serum-deprived PC12
cells. Both peptides caused prolonged cGMP (but not cAMP) elevations lasting for≥ 6 h.
The cGMP elevations were 10-, 50-and 68-fold for ANP and 26-, 100-and 148-fold for BNP
at 1, 10 and 100 nM, respectively. BNP caused dose-dependent increases in cell survival
rates during 3 days of serum deprivation. BNP (1 nM) increased 24 h survival rate from 36 …