[HTML][HTML] Effect of up-regulating individual steps in the reverse cholesterol transport pathway on reverse cholesterol transport in normolipidemic mice
K Alam, RS Meidell, DK Spady - Journal of Biological chemistry, 2001 - ASBMB
Cholesterol acquired by extrahepatic tissues (from de novo synthesis or lipoproteins) is
returned to the liver for excretion in a process called reverse cholesterol transport (RCT). We
undertook studies to determine if RCT could be enhanced by up-regulating individual steps
in the RCT pathway. Overexpression of 7α-hydroxylase, Scavenger receptor B1, lecithin:
cholesterol acyltransferase (LCAT), or apoA-I in the liver did not stimulate cholesterol efflux
from any extrahepatic tissue. In contrast, infusion of apoA-I· phospholipid complexes (rHDL) …
returned to the liver for excretion in a process called reverse cholesterol transport (RCT). We
undertook studies to determine if RCT could be enhanced by up-regulating individual steps
in the RCT pathway. Overexpression of 7α-hydroxylase, Scavenger receptor B1, lecithin:
cholesterol acyltransferase (LCAT), or apoA-I in the liver did not stimulate cholesterol efflux
from any extrahepatic tissue. In contrast, infusion of apoA-I· phospholipid complexes (rHDL) …