[HTML][HTML] Coupling endoplasmic reticulum stress to the cell death program
RV Rao, E Hermel, S Castro-Obregon, G del Rio… - Journal of Biological …, 2001 - ASBMB
The endoplasmic reticulum (ER) is the site of assembly of polypeptide chains destined for
secretion or routing into various subcellular compartments. It also regulates cellular
responses to stress and intracellular Ca 2+ levels. A variety of toxic insults can result in ER
stress that ultimately leads to apoptosis. Apoptosis is initiated by the activation of members
of the caspase family and serves as a central mechanism in the cell death process. The
present study was carried out to determine the role of caspases in triggering ER stress …
secretion or routing into various subcellular compartments. It also regulates cellular
responses to stress and intracellular Ca 2+ levels. A variety of toxic insults can result in ER
stress that ultimately leads to apoptosis. Apoptosis is initiated by the activation of members
of the caspase family and serves as a central mechanism in the cell death process. The
present study was carried out to determine the role of caspases in triggering ER stress …