Caspases involved in ER stress-mediated cell death
T Momoi - Journal of chemical neuroanatomy, 2004 - Elsevier
Caspases are cysteine proteases involved in apoptotic pathways. Excess endoplasmic
reticulum (ER) stress, induced by the accumulation of unfolded or malfolded proteins,
activates various apoptotic pathways. Crosstalk between the mitochondria and ER plays an
essential role in ER stress-mediated cell death. The cytochrome c-dependent apoptotic
pathway is activated by ER stress. On the other hand, caspase-12, which is located at the
ER, is also activated by excess ER stress and results in cell death in the absence of the …
reticulum (ER) stress, induced by the accumulation of unfolded or malfolded proteins,
activates various apoptotic pathways. Crosstalk between the mitochondria and ER plays an
essential role in ER stress-mediated cell death. The cytochrome c-dependent apoptotic
pathway is activated by ER stress. On the other hand, caspase-12, which is located at the
ER, is also activated by excess ER stress and results in cell death in the absence of the …