The unfolded protein response—a stress signaling pathway of the endoplasmic reticulum
X Shen, K Zhang, RJ Kaufman - Journal of chemical neuroanatomy, 2004 - Elsevier
The endoplasmic reticulum (ER) is a factory for folding and maturation of newly synthesized
transmembrane and secretory proteins. The ER provides stringent quality control systems to
ensure that only correctly folded proteins exit the ER and unfolded or misfolded proteins are
retained and ultimately degraded. A number of biochemical and physiological stimuli can
change ER homeostasis, impose stress to the ER, and subsequently lead to accumulation of
unfolded or misfolded proteins in the ER lumen. The ER has evolved stress response …
transmembrane and secretory proteins. The ER provides stringent quality control systems to
ensure that only correctly folded proteins exit the ER and unfolded or misfolded proteins are
retained and ultimately degraded. A number of biochemical and physiological stimuli can
change ER homeostasis, impose stress to the ER, and subsequently lead to accumulation of
unfolded or misfolded proteins in the ER lumen. The ER has evolved stress response …