Endoplasmic reticulum stress and diabetes mellitus
E Araki, S Oyadomari, M Mori - Internal medicine, 2003 - jstage.jst.go.jp
E Araki, S Oyadomari, M Mori
Internal medicine, 2003•jstage.jst.go.jpPancreatic p-cells are strongly engagedin protein secretion and have highly developed
endoplasmic reticulum (ER). Proper folding of polypeptide into a threedimensional structure
is essential for cellular function and protein malfolding can threaten cell survival. Various
conditions can perturb the protein folding in the ER, which is collectively called ERstress. In
order to adapt ERstress conditions, the cells respond in three distinct wayssuch as
transcriptional induction of ERchap-
endoplasmic reticulum (ER). Proper folding of polypeptide into a threedimensional structure
is essential for cellular function and protein malfolding can threaten cell survival. Various
conditions can perturb the protein folding in the ER, which is collectively called ERstress. In
order to adapt ERstress conditions, the cells respond in three distinct wayssuch as
transcriptional induction of ERchap-
Abstract
Pancreatic p-cells are strongly engagedin protein secretion and have highly developed endoplasmic reticulum (ER). Proper folding of polypeptide into a threedimensional structure is essential for cellular function and protein malfolding can threaten cell survival. Various conditions can perturb the protein folding in the ER, which is collectively called ERstress. In order to adapt ERstress conditions, the cells respond in three distinct wayssuch as transcriptional induction of ERchap-
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