[HTML][HTML] Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation
KM Murphy, UN Streips, RB Lock - Journal of Biological Chemistry, 2000 - ASBMB
Members of the Bcl-2 family of proteins control the cellular commitment to apoptosis,
although their role in Fas-induced apoptosis is ill-defined. In this report we demonstrate that
activation of the Fas receptor present on a human breast epithelial cell line resulted in a
conformational change in the N terminus of the pro-apoptotic protein Bax. This
conformational change appeared to occur in the cytosol and precede Bax translocation to
the mitochondria. Overexpression of the anti-apoptotic protein Bcl-2 inhibited both the …
although their role in Fas-induced apoptosis is ill-defined. In this report we demonstrate that
activation of the Fas receptor present on a human breast epithelial cell line resulted in a
conformational change in the N terminus of the pro-apoptotic protein Bax. This
conformational change appeared to occur in the cytosol and precede Bax translocation to
the mitochondria. Overexpression of the anti-apoptotic protein Bcl-2 inhibited both the …