[HTML][HTML] The small heat shock protein αB-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3
MC Kamradt, M Lu, ME Werner, T Kwan, F Chen… - Journal of Biological …, 2005 - ASBMB
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor
necrosis factor α family of cytokines that preferentially induces apoptosis in transformed
cells, making it a promising cancer therapy. However, many neoplasms are resistant to
TRAIL-induced apoptosis by mechanisms that are poorly understood. We demonstrate that
the expression of the small heat shock protein αB-crystallin (but not other heat shock
proteins or apoptosis-regulating proteins) correlates with TRAIL resistance in a panel of …
necrosis factor α family of cytokines that preferentially induces apoptosis in transformed
cells, making it a promising cancer therapy. However, many neoplasms are resistant to
TRAIL-induced apoptosis by mechanisms that are poorly understood. We demonstrate that
the expression of the small heat shock protein αB-crystallin (but not other heat shock
proteins or apoptosis-regulating proteins) correlates with TRAIL resistance in a panel of …