[HTML][HTML] Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1
R Steel, JP Doherty, K Buzzard, N Clemons… - Journal of Biological …, 2004 - ASBMB
Hsp72 protects cells against apoptosis in response to various stresses. By simultaneously
measuring cytochrome c localization and nuclear morphology in mouse embryo fibroblasts,
we have shown that Hsp72 blocks cytochrome c release from mitochondria in response to
cytotoxic stress and that permeabilization of the outer mitochondrial membrane is the critical
point in deciding the fate of the cell. Hsp72 did not inhibit apoptosis in mouse embryo
fibroblasts once cytochrome c had been released from the mitochondria. Recent reports …
measuring cytochrome c localization and nuclear morphology in mouse embryo fibroblasts,
we have shown that Hsp72 blocks cytochrome c release from mitochondria in response to
cytotoxic stress and that permeabilization of the outer mitochondrial membrane is the critical
point in deciding the fate of the cell. Hsp72 did not inhibit apoptosis in mouse embryo
fibroblasts once cytochrome c had been released from the mitochondria. Recent reports …