[HTML][HTML] Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas …
A Gross, XM Yin, K Wang, MC Wei, J Jockel… - Journal of Biological …, 1999 - ASBMB
" BH3 domain only" members of the BCL-2 family including the pro-apoptotic molecule BID
represent candidates to connect with proximal signal transduction. Tumor necrosis factor α
(TNFα) treatment induced a caspase-mediated cleavage of cytosolic, inactive p22 BID at
internal Asp sites to yield a major p15 and minor p13 and p11 fragments. p15 BID
translocates to mitochondria as an integral membrane protein. p15 BID within cytosol
targeted normal mitochondria and released cytochrome c. Immunodepletion of p15 BID …
represent candidates to connect with proximal signal transduction. Tumor necrosis factor α
(TNFα) treatment induced a caspase-mediated cleavage of cytosolic, inactive p22 BID at
internal Asp sites to yield a major p15 and minor p13 and p11 fragments. p15 BID
translocates to mitochondria as an integral membrane protein. p15 BID within cytosol
targeted normal mitochondria and released cytochrome c. Immunodepletion of p15 BID …