Many studies have illustrated that the production of reactive oxygen species (ROS) is
important for optimal tyrosine phosphorylation and signaling in response to diverse stimuli.
Protein-tyrosine phosphatases (PTPs), which are important regulators of signal transduction,
are exquisitely sensitive to inhibition after generation of ROS, and reversible oxidation is
becoming recognized as a general physiological mechanism for regulation of PTP function.
Thus, production of ROS facilitates a tyrosine phosphorylation-dependent cellular signaling …