The nuclear factor of κB (NF-κB) family of heterodimeric transcription factors plays an
instrumental role in immune, inflammatory, and stress responses. NF-κB induces the
expression of diverse target genes that promote cell cycle progression, regulate apoptosis,
and facilitate cell adhesion, angiogenesis, and metastasis. Given the ability of NF-κB to
influence these cardinal features of neoplastic transformation, it is no surprise that tumor
cells of almost every tissue type acquire the ability to constitutively activate NF-κB via a host …