[HTML][HTML] Role of pim-1 in smooth muscle cell proliferation
N Katakami, H Kaneto, H Hao, Y Umayahara… - Journal of Biological …, 2004 - ASBMB
The proliferation of vascular smooth muscle cells (VSMCs) and alterations of their
phenotype are implicated in the pathogenesis of atherosclerosis. Arterial wall injury induces
the expression of proto-oncogenes, leading to the proliferation of VSMCs. In particular, c-
Myc and c-Myb play a central role in cell cycle progression and are essential for VSMC
replication. The protooncogene Pim-1 cooperates with c-Myc and enhances the
transcriptional activity of c-Myb in hematopoietic cells, suggesting that Pim-1 is involved in …
phenotype are implicated in the pathogenesis of atherosclerosis. Arterial wall injury induces
the expression of proto-oncogenes, leading to the proliferation of VSMCs. In particular, c-
Myc and c-Myb play a central role in cell cycle progression and are essential for VSMC
replication. The protooncogene Pim-1 cooperates with c-Myc and enhances the
transcriptional activity of c-Myb in hematopoietic cells, suggesting that Pim-1 is involved in …