Pim‐1 expression in prostatic intraepithelial neoplasia and human prostate cancer
A Valdman, X Fang, ST Pang, P Ekman… - The Prostate, 2004 - Wiley Online Library
A Valdman, X Fang, ST Pang, P Ekman, L Egevad
The Prostate, 2004•Wiley Online LibraryBackground PIM‐1, an oncogene product of serine/threonine kinase, has been found to play
an important role in induction/suppression of apoptosis, cell cycle progression, and
transcriptional regulation by phosphorylating the target proteins involved in these processes.
Recently, the expression of PIM‐1 has been shown to correlate significantly with measures
of prostate cancer clinical outcome. Methods Immunohistochemical analysis was used to
characterize the patterns of PIM‐1 expression in high grade prostatic intraepithelial …
an important role in induction/suppression of apoptosis, cell cycle progression, and
transcriptional regulation by phosphorylating the target proteins involved in these processes.
Recently, the expression of PIM‐1 has been shown to correlate significantly with measures
of prostate cancer clinical outcome. Methods Immunohistochemical analysis was used to
characterize the patterns of PIM‐1 expression in high grade prostatic intraepithelial …
Background
PIM‐1, an oncogene product of serine/threonine kinase, has been found to play an important role in induction/suppression of apoptosis, cell cycle progression, and transcriptional regulation by phosphorylating the target proteins involved in these processes. Recently, the expression of PIM‐1 has been shown to correlate significantly with measures of prostate cancer clinical outcome.
Methods
Immunohistochemical analysis was used to characterize the patterns of PIM‐1 expression in high grade prostatic intraepithelial neoplasia (HGPIN) and cancer in 121 radical prostatectomy specimens.
Results
Moderate to strong cytoplasmic staining was observed in 68% of cancers, 12% presented nuclear positivity as well. Moderate to strong expression was seen in 76% of tumors with Gleason score (GS) 7 or higher compared to 58% in tumors with GS 6 or lower (P = 0.04). The staining intensity was moderate or strong in 97% of HGPIN lesions. PIM‐1 was overexpressed in HGPIN compared to cancer in 65% of cases. Expression in benign glands was negative or only weakly positive.
Conclusion
Our data suggest that PIM‐1 overexpression in HGPIN may be an early event in the development of prostate malignancy. Additionally, PIM‐1 expression provides supplementary information for distinguishing HGPIN from benign epithelium. © 2004 Wiley‐Liss, Inc.
Wiley Online Library