[HTML][HTML] Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology
A comparison of Akt-and Bcl-x L-dependent cell survival was undertaken using interleukin-3-
dependent FL5. 12 cells. Expression of constitutively active Akt allows cells to survive for
prolonged periods following growth factor withdrawal. This survival correlates with the
expression level of activated Akt and is comparable in magnitude to the protection provided
by the anti-apoptotic geneBcl-x L. Although both genes prevent cell death, Akt-protected
cells can be distinguished fromBcl-x L-protected cells on the basis of increased glucose …
dependent FL5. 12 cells. Expression of constitutively active Akt allows cells to survive for
prolonged periods following growth factor withdrawal. This survival correlates with the
expression level of activated Akt and is comparable in magnitude to the protection provided
by the anti-apoptotic geneBcl-x L. Although both genes prevent cell death, Akt-protected
cells can be distinguished fromBcl-x L-protected cells on the basis of increased glucose …