[HTML][HTML] Bone mineral density and urine calcium excretion among subjects with and without nephrolithiasis
JR Asplin, KA Bauer, J Kinder, G Müller, BJ Coe… - Kidney international, 2003 - Elsevier
Kidney international, 2003•Elsevier
Bone mineral density and urine calcium excretion among subjects with and without
nephrolithiasis. Background Bone mineral density (BMD) is reduced among patients with
idiopathic hypercalciuria (IH) and nephrolithiasis. To disentangle effects of diet, stone
formation, and physiology upon BMD, we studied vertebral and femoral neck BMD among
relatives of hypercalciuric stone formers, and contrasted those with to those without stones.
Methods Among 59 subjects from 11 families, vertebral and femoral neck BMD, diet calcium …
nephrolithiasis. Background Bone mineral density (BMD) is reduced among patients with
idiopathic hypercalciuria (IH) and nephrolithiasis. To disentangle effects of diet, stone
formation, and physiology upon BMD, we studied vertebral and femoral neck BMD among
relatives of hypercalciuric stone formers, and contrasted those with to those without stones.
Methods Among 59 subjects from 11 families, vertebral and femoral neck BMD, diet calcium …
Bone mineral density and urine calcium excretion among subjects with and without nephrolithiasis.
Background
Bone mineral density (BMD) is reduced among patients with idiopathic hypercalciuria (IH) and nephrolithiasis. To disentangle effects of diet, stone formation, and physiology upon BMD, we studied vertebral and femoral neck BMD among relatives of hypercalciuric stone formers, and contrasted those with to those without stones.
Methods
Among 59 subjects from 11 families, vertebral and femoral neck BMD, diet calcium intake, urine excretions of calcium, sodium, ammonium, titratable acid, sulfate, urea nitrogen, and serum levels of calcitriol and markers of bone turnover were studied.
Results
Stone formers (SF) consumed less calcium than non-stone formers (NSF). Spine and femoral neck BMD z-scores varied inversely with urine calcium loss and urine ammonium excretion among SF but not NSF. No correlations of BMD z-score were found for bone markers, calcitriol, or any of the other measurements.
Conclusion
SF consumed less calcium, presumably to prevent more stones, and displayed a bone mineral responsiveness to calcium loss and ammonium excretion not present among NSF, who ate more calcium. Lowered calcium consumption in IH, perhaps in response to stone formation, alters bone responses in a direction that can predispose to mineral loss and eventual fracture.
Elsevier