Structure and function of the glucocorticoid receptor ligand binding domain
RK Bledsoe, EL Stewart, KH Pearce - Vitamins & Hormones, 2004 - Elsevier
After binding to an activating ligand, such as corticosteroid, the glucocorticoid receptor (GR)
performs an impressive array of functions ranging from nuclear translocation,
oligomerization, cofactor⧸ kinase⧸ transcription factor association, and DNA binding. One of
the central functions of the receptor is to regulate gene expression, an activity triggered by
ligand binding. In this role, GR acts as an adapter molecule by encoding the ligand's
message within the structural flexibility of the ligand binding domain (LBD). The purpose of …
performs an impressive array of functions ranging from nuclear translocation,
oligomerization, cofactor⧸ kinase⧸ transcription factor association, and DNA binding. One of
the central functions of the receptor is to regulate gene expression, an activity triggered by
ligand binding. In this role, GR acts as an adapter molecule by encoding the ligand's
message within the structural flexibility of the ligand binding domain (LBD). The purpose of …
