Differentiation status of rat ductal cells and ethionine-induced hepatic carcinomas defined with surface-reactive monoclonal antibodies
DC Hixson, J Brown, AC McBride, S Affigne - Experimental and molecular …, 2000 - Elsevier
To gain further insight into the differentiation of oval cells and their role in carcinogenesis,
we have generated cell surface reactive monoclonal antibodies (MAbs) by a Balb/c nude
mouse (nu/nu) immunization protocol. Three MAbs designated OC. 4, OC. 5, and OC. 10
were generated from a mouse immunized with CDE6, an oval cell line established from oval
cells induced by feeding a choline-deficient diet containing 0.1% ethionine (CDE). These
MAbs demonstrated stage-specific expression in fetal liver and displayed strong reactivity …
we have generated cell surface reactive monoclonal antibodies (MAbs) by a Balb/c nude
mouse (nu/nu) immunization protocol. Three MAbs designated OC. 4, OC. 5, and OC. 10
were generated from a mouse immunized with CDE6, an oval cell line established from oval
cells induced by feeding a choline-deficient diet containing 0.1% ethionine (CDE). These
MAbs demonstrated stage-specific expression in fetal liver and displayed strong reactivity …