In vivoinfusion of growth factors enhances the mitogenic response of rat hepatic ductal (oval) cells after administration of 2-acetylaminofluorene
P Nagy, HC Bisgaard, E Santoni-Rugiu… - Hepatology, 1996 - journals.lww.com
Expression of several growth factors is elevated in rat liver, after induction of oval cell
proliferation by chemical carcinogens. However, the exact roles played by individual factors
are not defined. We infused and examined the effects of epidermal growth factor (EGF) and
hepatocyte growth factor (HGF) on the proliferation of ductal and periductal cells after their
activation with 2-acetylaminofluorene (2-AAF). Furthermore, we included studies on
urokinase-type plasminogen activator (uPA), because Northern blot analysis showed a …
proliferation by chemical carcinogens. However, the exact roles played by individual factors
are not defined. We infused and examined the effects of epidermal growth factor (EGF) and
hepatocyte growth factor (HGF) on the proliferation of ductal and periductal cells after their
activation with 2-acetylaminofluorene (2-AAF). Furthermore, we included studies on
urokinase-type plasminogen activator (uPA), because Northern blot analysis showed a …