Angiogenesis
J Folkman - Biology of endothelial cells, 1984 - Springer
Angiogenesis Page 1 CHAPTER 42 Angiogenesis JUDAH FOLKMAN I. Introduction
Angiogenesis is the generation of new capillary blood vessels. While all subsequent vessels,
including the aorta, originate from capillaries, the term angiogenesis is commonly used to refer
only to growth of new capillaries. Interest in angiogenesis has increased during the past
decade, aroused, in part, by the experimental observations that the progressive growth of solid
tumors and their metastases depends upon the continuous induction of new capillary blood …
Angiogenesis is the generation of new capillary blood vessels. While all subsequent vessels,
including the aorta, originate from capillaries, the term angiogenesis is commonly used to refer
only to growth of new capillaries. Interest in angiogenesis has increased during the past
decade, aroused, in part, by the experimental observations that the progressive growth of solid
tumors and their metastases depends upon the continuous induction of new capillary blood …
Angiogenesis
J Folkman - Annu. Rev. Med., 2006 - annualreviews.org
Angiogenesis inhibitors for the treatment of cancer have now been approved by the Food
and Drug Administration in the United States, and in 28 other countries including China.
Clinical application of this new class of drugs is informed by certain principles from
angiogenesis research. Oncogenic mutations initiate tumorigenesis, but angiogenesis is
necessary for expansion of tumor mass. Two angiogenesis inhibitors have been developed
that have a broad spectrum of anticancer activity, yet virtually no side effects. Endogenous …
and Drug Administration in the United States, and in 28 other countries including China.
Clinical application of this new class of drugs is informed by certain principles from
angiogenesis research. Oncogenic mutations initiate tumorigenesis, but angiogenesis is
necessary for expansion of tumor mass. Two angiogenesis inhibitors have been developed
that have a broad spectrum of anticancer activity, yet virtually no side effects. Endogenous …
Tumor angiogenesis
J Folkman - Advances in cancer research, 1985 - Elsevier
Publisher Summary Angiogenesis occurs during embryonic development and during
several physiological and pathological conditions in adult life. Solid tumors induce
angiogenesis. However, tumor angiogenesis differs at least in a temporal way from the other
types of angiogenesis. In certain nonmalignant processes, angiogenesis is abnormally
prolonged, although still self-limited, as in pyogenic granuloma or keloid formation. By
contrast, tumor angiogenesis is not self-limited. Once tumor-induced angiogenesis begins, it …
several physiological and pathological conditions in adult life. Solid tumors induce
angiogenesis. However, tumor angiogenesis differs at least in a temporal way from the other
types of angiogenesis. In certain nonmalignant processes, angiogenesis is abnormally
prolonged, although still self-limited, as in pyogenic granuloma or keloid formation. By
contrast, tumor angiogenesis is not self-limited. Once tumor-induced angiogenesis begins, it …
Clinical applications of research on angiogenesis
J Folkman - New England Journal of Medicine, 1995 - Mass Medical Soc
Angiogenesis is fundamental to reproduction, development, and repair. All these processes
depend on the tightly regulated growth of blood vessels that can “turn on” and “turn off”
within a brief period. When blood vessels grow unabated, angiogenesis becomes
pathologic and sustains the progression of many neoplastic and non-neoplastic diseases.
The realization that tumor growth requires new blood vessels and the identification of
chemical factors that mediate angiogenesis have broadened our understanding of …
depend on the tightly regulated growth of blood vessels that can “turn on” and “turn off”
within a brief period. When blood vessels grow unabated, angiogenesis becomes
pathologic and sustains the progression of many neoplastic and non-neoplastic diseases.
The realization that tumor growth requires new blood vessels and the identification of
chemical factors that mediate angiogenesis have broadened our understanding of …