Analysis of neuropeptide Y-induced feeding: dissociation of Y1 and Y2 receptor effects on natural meal patterns
SF Leibowitz, JT Alexander - Peptides, 1991 - Elsevier
To differentiate NPY receptor subtypes, Y 1 and Y 2, in terms of their impact on feeding
behavior, the intact molecule NPY (1–36) and the 3 fragments, NPY (2–36), the Y 1 agonist
[Leu 31, Pro 34] NPY, and the Y 2 agonist NPY (13–36), were injected (100 pmol/0.3 μl) into
the hypothalamic paraventricular nucleus (PVN) of freely feeding rats. A computer-
automated data acquisition system was employed in these experiments to permit a detailed
analysis of feeding over the 12-h nocturnal cycle, in animals maintained on pure …
behavior, the intact molecule NPY (1–36) and the 3 fragments, NPY (2–36), the Y 1 agonist
[Leu 31, Pro 34] NPY, and the Y 2 agonist NPY (13–36), were injected (100 pmol/0.3 μl) into
the hypothalamic paraventricular nucleus (PVN) of freely feeding rats. A computer-
automated data acquisition system was employed in these experiments to permit a detailed
analysis of feeding over the 12-h nocturnal cycle, in animals maintained on pure …