[HTML][HTML] Biochemical Differences in the αβ T Cell Receptor· CD3 Surface Complex between CD8+ and CD4+ Human Mature T Lymphocytes
DA Zapata, WWA Schamel, PS Torres, B Alarcón… - Journal of Biological …, 2004 - ASBMB
We have reported the existence of biochemical and conformational differences in the αβ T
cell receptor (TCR) complex between CD4+ and CD8+ CD3γ-deficient (γ-) mature T cells. In
the present study, we have furthered our understanding and extended the observations to
primary T lymphocytes from normal (γ+) individuals. Surface TCR· CD3 components from
CD4+ γ-T cells, other than CD3γ, were detectable and similar in size to CD4+ γ+ controls.
Their native TCR· CD3 complex was also similar to CD4+ γ+ controls, except for an αβ (δϵ) …
cell receptor (TCR) complex between CD4+ and CD8+ CD3γ-deficient (γ-) mature T cells. In
the present study, we have furthered our understanding and extended the observations to
primary T lymphocytes from normal (γ+) individuals. Surface TCR· CD3 components from
CD4+ γ-T cells, other than CD3γ, were detectable and similar in size to CD4+ γ+ controls.
Their native TCR· CD3 complex was also similar to CD4+ γ+ controls, except for an αβ (δϵ) …
