[HTML][HTML] Genetic heterogeneity in the apolipoprotein C-III promoter and effects of insulin
GM Dallinga-Thie, M Groenendijk, RN Blom… - Journal of lipid …, 2001 - ASBMB
In the present study, we have investigated the in vivo and in vitro role of two newly identified
variants (G− 944 A and A− 1180 C) located in the upstream promoter region of the
apolipoprotein C-III (apoC-III) gene. These variants were studied in 30 probands diagnosed
with FCHL, their relatives, and spouses. The allele frequencies of both variants were not
different between the groups. No significant associations between plasma lipid traits and
DNA variants were observed. We further analyzed the effect of the presence of these …
variants (G− 944 A and A− 1180 C) located in the upstream promoter region of the
apolipoprotein C-III (apoC-III) gene. These variants were studied in 30 probands diagnosed
with FCHL, their relatives, and spouses. The allele frequencies of both variants were not
different between the groups. No significant associations between plasma lipid traits and
DNA variants were observed. We further analyzed the effect of the presence of these …
