Loss of heterozygosity in human skin
R Happle - Journal of the American Academy of Dermatology, 1999 - Elsevier
Loss of heterozygosity (LOH) is a genetic mechanism by which a heterozygous somatic cell
becomes either homozygous or hemizygous because the corresponding wild-type allele is
lost. LOH has today been recognized as a major cause of malignant growth. This article
gives a comprehensive review of skin disorders in which an origin from LOH has been either
documented at the molecular level or postulated on the basis of clinical evidence. LOH has
been shown to cause basal cell carcinoma, squamous cell carcinoma, and malignant …
becomes either homozygous or hemizygous because the corresponding wild-type allele is
lost. LOH has today been recognized as a major cause of malignant growth. This article
gives a comprehensive review of skin disorders in which an origin from LOH has been either
documented at the molecular level or postulated on the basis of clinical evidence. LOH has
been shown to cause basal cell carcinoma, squamous cell carcinoma, and malignant …
