Got RIP?: Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling
N Landman, TW Kim - Cytokine & growth factor reviews, 2004 - Elsevier
A number of cell surface growth factor receptors are subject to presenilin-dependent
regulated intramembrane proteolysis (PS-RIP) after ligand binding and/or ectodomain
cleavage. PS-RIP is mediated by a highly conserved multi-component membrane-bound
protease, termed γ-secretase, responsible for generating Alzheimer's disease (AD)-
associated Aβ peptide from its membrane-bound β-amyloid precursor protein (APP), as well
as for cleaving a number of other type-I membrane receptors. PS-RIP is a conserved cellular …
regulated intramembrane proteolysis (PS-RIP) after ligand binding and/or ectodomain
cleavage. PS-RIP is mediated by a highly conserved multi-component membrane-bound
protease, termed γ-secretase, responsible for generating Alzheimer's disease (AD)-
associated Aβ peptide from its membrane-bound β-amyloid precursor protein (APP), as well
as for cleaving a number of other type-I membrane receptors. PS-RIP is a conserved cellular …
