Selective expression of an interleukin-12 receptor component by human T helper 1 cells
L Rogge, L Barberis-Maino, M Biffi, N Passini… - The Journal of …, 1997 - rupress.org
L Rogge, L Barberis-Maino, M Biffi, N Passini, DH Presky, U Gubler, F Sinigaglia
The Journal of experimental medicine, 1997•rupress.orgInterleukin-12 (IL-12), a heterodimeric cytokine produced by activated monocytes and
dendritic cells, plays a crucial role in regulating interferon (IFN)-γ production and in the
generation of IFN–γ–producing T helper 1 (Th1) cells. Here we show that the IL-12 receptor
(IL12R) β2 subunit, a recently cloned binding and signal transducing component of the IL-
12R, is expressed on human Th1 but not Th2 clones and is induced during differentiation of
human naive cells along the Th1 but not the Th2 pathway. IL-12 and type I but not type II …
dendritic cells, plays a crucial role in regulating interferon (IFN)-γ production and in the
generation of IFN–γ–producing T helper 1 (Th1) cells. Here we show that the IL-12 receptor
(IL12R) β2 subunit, a recently cloned binding and signal transducing component of the IL-
12R, is expressed on human Th1 but not Th2 clones and is induced during differentiation of
human naive cells along the Th1 but not the Th2 pathway. IL-12 and type I but not type II …
Interleukin-12 (IL-12), a heterodimeric cytokine produced by activated monocytes and dendritic cells, plays a crucial role in regulating interferon (IFN)-γ production and in the generation of IFN–γ–producing T helper 1 (Th1) cells. Here we show that the IL-12 receptor (IL12R) β2 subunit, a recently cloned binding and signal transducing component of the IL-12R, is expressed on human Th1 but not Th2 clones and is induced during differentiation of human naive cells along the Th1 but not the Th2 pathway. IL-12 and type I but not type II interferons induce expression of the IL-12R β2 chain during in vitro T cell differentiation after antigen receptor triggering. The selective expression and regulation of the IL-12R β2 subunit may help to understand the basis of Th1/Th2 differentiation and may provide therapeutic options for altering the Th1/Th2 balance in several immuno-pathological conditions such as autoimmune diseases and allergies.
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