[HTML][HTML] Foxa2 (HNF3β) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release
H Wang, BR Gauthier… - Journal of Biological …, 2002 - ASBMB
The transcription factor Foxa2 is implicated in blood glucose homeostasis. Conditional
expression of Foxa2 or its dominant-negative mutant DN-Foxa2 in INS-1 cells reveals that
Foxa2 regulates the expression of genes important for glucose sensing in pancreatic β-cells.
Overexpression of Foxa2 results in blunted glucose-stimulated insulin secretion, whereas
induction of DN-Foxa2 causes a left shift of glucose-induced insulin release. The mRNA
levels of GLUT2 and glucokinase are drastically decreased after induction of Foxa2. In …
expression of Foxa2 or its dominant-negative mutant DN-Foxa2 in INS-1 cells reveals that
Foxa2 regulates the expression of genes important for glucose sensing in pancreatic β-cells.
Overexpression of Foxa2 results in blunted glucose-stimulated insulin secretion, whereas
induction of DN-Foxa2 causes a left shift of glucose-induced insulin release. The mRNA
levels of GLUT2 and glucokinase are drastically decreased after induction of Foxa2. In …