Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in …
M Steinhoff, GP McGregor, A Radleff-Schlimme… - Regulatory peptides, 1999 - Elsevier
Morphological and biochemical evidence is presented for the presence of pituitary
adenylate cyclase activating peptide (PACAP) and the high-affinity PACAP-1 receptor
subtype in human skin. Immunohistochemical analysis revealed PACAP-immunoreactivity
(IR) to be present predominantly in dermal nerve fibers close to the dermal–epidermal
border, hair follicles, blood vessels and sweat glands. Radioimmunoassay, chromatographic
analysis and Western blotting revealed this PACAP-IR to be PACAP-38 whereas the second …
adenylate cyclase activating peptide (PACAP) and the high-affinity PACAP-1 receptor
subtype in human skin. Immunohistochemical analysis revealed PACAP-immunoreactivity
(IR) to be present predominantly in dermal nerve fibers close to the dermal–epidermal
border, hair follicles, blood vessels and sweat glands. Radioimmunoassay, chromatographic
analysis and Western blotting revealed this PACAP-IR to be PACAP-38 whereas the second …