[HTML][HTML] Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3β
E Smith, GA Coetzee, B Frenkel - Journal of biological chemistry, 2002 - ASBMB
Differentiating osteoblasts in culture undergo a commitment stage, during which
cobblestone-like cells grow to high density past confluency. In contrast to earlier proliferative
stages, the cell cycle during this commitment stage is inhibited by glucocorticoids (GC).
Chronic GC treatment also impedes mineral deposition if steroid administration commences
early enough during commitment. This study defines a role for glycogen synthase kinase-3β
(GSK3β) and its target, c-Myc, in the GC-sensitive osteoblast persistent cell cycle. c-Myc …
cobblestone-like cells grow to high density past confluency. In contrast to earlier proliferative
stages, the cell cycle during this commitment stage is inhibited by glucocorticoids (GC).
Chronic GC treatment also impedes mineral deposition if steroid administration commences
early enough during commitment. This study defines a role for glycogen synthase kinase-3β
(GSK3β) and its target, c-Myc, in the GC-sensitive osteoblast persistent cell cycle. c-Myc …
