Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities

PO Vidalain, O Azocar, C Rabourdin-Combe… - Immunobiology, 2001 - Elsevier
Measle virus (MV) infection induces a transient but profound immunosuppression
characterized by a panlymphopenia which occasionally results in opportunistic infections
responsible for a high rate of mortality in malnourished children. MV can encounter human
dendritic cells (DC) in the respiratory mucosa or in the secondary lymphoid organs. After a
brief presentation of DCs, we review progress in understanding the immunobiology of MV-
infected DCs that could account for MV-induced immunosuppression. In addition, we …