The incidence of atopic dermatitis is increasing, and this poses a major burden on health
care costs. A precise understanding of the genetic and immunologic mechanisms is crucial
for development of effective treatment strategies for atopic dermatitis. Various studies
indicate that it has a multifactorial cause, with activation of complex immunologic and
inflammatory pathways. The current review will examine recent advances that have been
made in our understanding of the genetic and pathophysiologic prerequisites that form the …