Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations
M Kabesch, W Peters, D Carr, W Leupold… - Journal of allergy and …, 2003 - Elsevier
Background: Early exposure to microbial matter such as LPS may influence the
development of asthma and allergies by activation of innate immunity pathways as indicated
by studies in farming environments. Recently, polymorphisms in caspase recruitment
domain containing protein 15 (CARD15), an intracellular LPS receptor protein, have been
associated with Crohn's disease. Because these polymorphisms lead to changes in LPS
recognition, they may affect the development of asthma and allergies. Objective: We …
development of asthma and allergies by activation of innate immunity pathways as indicated
by studies in farming environments. Recently, polymorphisms in caspase recruitment
domain containing protein 15 (CARD15), an intracellular LPS receptor protein, have been
associated with Crohn's disease. Because these polymorphisms lead to changes in LPS
recognition, they may affect the development of asthma and allergies. Objective: We …