[HTML][HTML] Attenuation of Helicobacter pylori CagA· SHP-2 signaling by interaction between CagA and C-terminal Src kinase
R Tsutsumi, H Higashi, M Higuchi, M Okada… - Journal of Biological …, 2003 - ASBMB
Helicobacter pylori (H. pylori) is a causative agent of gastric diseases ranging from gastritis
to cancer. The CagA protein is the product of thecagA gene carried among virulent H.
pyloristrains and is associated with severe disease outcomes, most notably gastric
carcinoma. CagA is injected from the attached H. pylori into gastric epithelial cells and
undergoes tyrosine phosphorylation. The phosphorylated CagA binds and activates SHP-2
phosphatase and thereby induces a growth factor-like morphological change termed the" …
to cancer. The CagA protein is the product of thecagA gene carried among virulent H.
pyloristrains and is associated with severe disease outcomes, most notably gastric
carcinoma. CagA is injected from the attached H. pylori into gastric epithelial cells and
undergoes tyrosine phosphorylation. The phosphorylated CagA binds and activates SHP-2
phosphatase and thereby induces a growth factor-like morphological change termed the" …