Interfering with leukocyte rolling–a promising therapeutic approach in inflammatory skin disorders?
WH Boehncke, MP Schön - Trends in pharmacological sciences, 2003 - cell.com
WH Boehncke, MP Schön
Trends in pharmacological sciences, 2003•cell.comMany novel anti-inflammatory compounds have been derived from research tools designed
to better understand the complex process of leukocyte extravasation at sites of inflammation.
Given that selectin-mediated rolling is the crucial initial step of leukocyte localization to the
skin, specific interference with this mechanism is a particularly attractive target to treat
cutaneous inflammation. Recently, several exciting advances have been reported aimed at
selective interference with specific target molecules crucially involved in leukocyte rolling.
to better understand the complex process of leukocyte extravasation at sites of inflammation.
Given that selectin-mediated rolling is the crucial initial step of leukocyte localization to the
skin, specific interference with this mechanism is a particularly attractive target to treat
cutaneous inflammation. Recently, several exciting advances have been reported aimed at
selective interference with specific target molecules crucially involved in leukocyte rolling.
Abstract
Many novel anti-inflammatory compounds have been derived from research tools designed to better understand the complex process of leukocyte extravasation at sites of inflammation. Given that selectin-mediated rolling is the crucial initial step of leukocyte localization to the skin, specific interference with this mechanism is a particularly attractive target to treat cutaneous inflammation. Recently, several exciting advances have been reported aimed at selective interference with specific target molecules crucially involved in leukocyte rolling.
cell.com