Enhanced protection from renal ischemia-reperfusion [correction of ischemia: reperfusion] injury with A (2A)-adenosine receptor activation and PDE 4 inhibition.
MD Okusa, J Linden, L Huang, DL Rosin… - Kidney …, 2001 - europepmc.org
Background We previously demonstrated in rats and mice that agonists of A (2A)-adenosine
receptors (A (2A)-ARs) reduce renal injury following ischemia-reperfusion. We now extend
these studies and examine the effects of ATL-146e (formerly DWH-146e), an A (2A)-AR
agonist, and rolipram, a type IV phosphodiesterase (PDE 4) inhibitor, on murine renal injury
following ischemia-reperfusion. Methods C57BL/6 mice were treated with rolipram, ATL-
146e, or both compounds combined and were subjected to renal ischemia for 32 minutes …
receptors (A (2A)-ARs) reduce renal injury following ischemia-reperfusion. We now extend
these studies and examine the effects of ATL-146e (formerly DWH-146e), an A (2A)-AR
agonist, and rolipram, a type IV phosphodiesterase (PDE 4) inhibitor, on murine renal injury
following ischemia-reperfusion. Methods C57BL/6 mice were treated with rolipram, ATL-
146e, or both compounds combined and were subjected to renal ischemia for 32 minutes …
[HTML][HTML] Enhanced protection from renal ischemia: Reperfusion injury with A2A-adenosine receptor activation and PDE 4 inhibition
Enhanced protection from renal ischemia: Reperfusion injury with A 2A-adenosine receptor
activation and PDE 4 inhibition. Background We previously demonstrated in rats and mice
that agonists of A 2A-adenosine receptors (A 2A-ARs) reduce renal injury following ischemia-
reperfusion. We now extend these studies and examine the effects of ATL-146e (formerly
DWH-146e), an A 2A-AR agonist, and rolipram, a type IV phosphodiesterase (PDE 4)
inhibitor, on murine renal injury following ischemia-reperfusion. Methods C57BL/6 mice …
activation and PDE 4 inhibition. Background We previously demonstrated in rats and mice
that agonists of A 2A-adenosine receptors (A 2A-ARs) reduce renal injury following ischemia-
reperfusion. We now extend these studies and examine the effects of ATL-146e (formerly
DWH-146e), an A 2A-AR agonist, and rolipram, a type IV phosphodiesterase (PDE 4)
inhibitor, on murine renal injury following ischemia-reperfusion. Methods C57BL/6 mice …
