Angiogenesis is the process of new capillary formation from previously existing mature
vessels. The adult ovary exhibits dramatic growth and regression of capillary networks on a
cyclic basis. Ovarian follicles and the corpus luteum contain and produce endothelial cell-
specific factors, which may act alone or in concert to regulate the process of angiogenesis.
These factors are ultimately controlled by endocrine, paracrine and autocrine regulation, as
well as by metabolic cellular signals such as intracellular oxygen content and ageing …