[HTML][HTML] Triggering of the human interleukin-6 gene by interferon-γ and tumor necrosis factor-α in monocytic cells involves cooperation between interferon regulatory …
J Sancéau, T Kaisho, T Hirano, J Wietzerbin - Journal of Biological …, 1995 - ASBMB
We investigated the molecular basis of the synergistic induction by interferon-γ (IFN-γ)/tumor
necrosis factor-α (TNF-α) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells, and
compared it with the basis of this induction by lipopolysaccharide (LPS). Functional studies
with IL-6 promoter demonstrated that three regions are the targets of the IFN-γ and/or TNF-α
action, whereas only one of these regions seemed to be implicated in LPS activation. The
three regions concerned are: 1) a region between-73 and-36, which is the minimal element …
necrosis factor-α (TNF-α) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells, and
compared it with the basis of this induction by lipopolysaccharide (LPS). Functional studies
with IL-6 promoter demonstrated that three regions are the targets of the IFN-γ and/or TNF-α
action, whereas only one of these regions seemed to be implicated in LPS activation. The
three regions concerned are: 1) a region between-73 and-36, which is the minimal element …
