Characterization of the IL-6 Responsive Elements in the γ Fibrinogen Gene Promoter (∗)
Z Zhang, NL Fuentes, GM Fuller - Journal of Biological Chemistry, 1995 - ASBMB
Fibrinogen, a hepatically derived class II acute phase protein, is the product of three
separate genes,(Aα, Bβ, and γ). The fibrinogen genes are expressed constitutively; however,
their transcription can be significantly up-regulated by interleukin-6 (IL-6) and glucocorticoid.
Inspection of the promoter region of the fibrinogen γ gene revealed three hexanucleotide
clusters of CTGGGA that are recognized as class II IL-6 responsive elements. Functional
analyses of these regions (designated here as site I, site II, and site III according to their …
separate genes,(Aα, Bβ, and γ). The fibrinogen genes are expressed constitutively; however,
their transcription can be significantly up-regulated by interleukin-6 (IL-6) and glucocorticoid.
Inspection of the promoter region of the fibrinogen γ gene revealed three hexanucleotide
clusters of CTGGGA that are recognized as class II IL-6 responsive elements. Functional
analyses of these regions (designated here as site I, site II, and site III according to their …
