Increased expression of KDR/Flk-1 (VEGFR-2) in murine model of ischemia-induced retinal neovascularization
K Suzuma, H Takagi, A Otani, I Suzuma, Y Honda - Microvascular research, 1998 - Elsevier
Although the vascular endothelial growth factor (VEGF)/VEGF receptor system plays a
critical role in the pathogenesis of ischemic retinal neovascular diseases such as diabetic
retinopathy, regulation of VEGF receptor expression in ischemic retina has not been fully
investigatedin vivo. Accordingly, we studied the regulation of Flt-1 (VEGFR-1) and KDR/Flk-1
(VEGFR-2) expression in a mouse model of ischemia-induced retinal neovascularization.
Immunohistochemistry for Flt-1 and KDR/Flk-1 revealed that, in hypoxic retina, the …
critical role in the pathogenesis of ischemic retinal neovascular diseases such as diabetic
retinopathy, regulation of VEGF receptor expression in ischemic retina has not been fully
investigatedin vivo. Accordingly, we studied the regulation of Flt-1 (VEGFR-1) and KDR/Flk-1
(VEGFR-2) expression in a mouse model of ischemia-induced retinal neovascularization.
Immunohistochemistry for Flt-1 and KDR/Flk-1 revealed that, in hypoxic retina, the …
