Evolution of a biosynthetic pathway: the tryptophan paradigm

IP Crawford - Annual Review of Microbiology, 1989 - annualreviews.org
IP Crawford
Annual Review of Microbiology, 1989annualreviews.org
Following the identification of the enzymes and reactions of tryptophan synthesis in fungi
and bacteria about 20 years ago, this pathway (Figure 1) and its regulation have been
studied extensively, probably in a greater variety of organisms than any other. Since the
comparative aspects of tryptophan synthesis were last reviewed (6, 8, 61) much new
information has appeared,
Following the identification of the enzymes and reactions of tryptophan synthesis in fungi and bacteria about 20 years ago, this pathway (Figure 1) and its regulation have been studied extensively, probably in a greater variety of organisms than any other. Since the comparative aspects of tryptophan synthesis were last reviewed (6, 8, 61) much new information has appeared,
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