[HTML][HTML] Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone …
HK Berman, RM O'Doherty, P Anderson… - Journal of Biological …, 1998 - ASBMB
Protein targeting to glycogen (PTG), also known as PPP1R5, is a widely expressed member
of a growing family of proteins that target protein phosphatase-1 (PP-1) to glycogen
particles. Because PTG also binds to glycogen synthase and phosphorylase kinase, it has
been suggested that it serves as a" scaffold" for efficient activation of glycogen synthesis.
However, very little is known about the metabolic effects of PTG. In this study, we have used
recombinant adenovirus to overexpress PTG in primary rat hepatocytes, a cell type with high …
of a growing family of proteins that target protein phosphatase-1 (PP-1) to glycogen
particles. Because PTG also binds to glycogen synthase and phosphorylase kinase, it has
been suggested that it serves as a" scaffold" for efficient activation of glycogen synthesis.
However, very little is known about the metabolic effects of PTG. In this study, we have used
recombinant adenovirus to overexpress PTG in primary rat hepatocytes, a cell type with high …