Lipid hydroperoxides are formed in vivo through free radical pathways from the action of
reactive oxygen species on polyunsaturated fatty acids. They are also formed as specific
products of lipoxygenases and cyclooxygenases. Homolytic decomposition of lipid
hydroperoxides to the α, β-unsaturated aldehyde genotoxins, 4-oxo-2-nonenal, 4, 5-epoxy-2
(E)-decenal, and 4-hydroxy-2-nonenal occurs through two quite distinct pathways. One
pathway involves a complex rearrangement of the alkoxy radical derived from the lipid …