[HTML][HTML] VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice
A Soriano, A Salas, A Salas, M Sans, M Gironella… - Laboratory …, 2000 - Elsevier
Adhesion molecule immunoneutralization is envisioned as a promising therapy for
inflammatory bowel disease, but the relative value of selective blockade of different
adhesion molecules has not been established. The aims of this study were to measure
expression and functional relevance of endothelial intercellular adhesion molecule 1 (ICAM-
1), vascular cell adhesion molecule 1 (VCAM-1), and mucosal addressin cell adhesion
molecule 1 (MAdCAM-1) in leukocyte recruitment in experimental colitis and to compare the …
inflammatory bowel disease, but the relative value of selective blockade of different
adhesion molecules has not been established. The aims of this study were to measure
expression and functional relevance of endothelial intercellular adhesion molecule 1 (ICAM-
1), vascular cell adhesion molecule 1 (VCAM-1), and mucosal addressin cell adhesion
molecule 1 (MAdCAM-1) in leukocyte recruitment in experimental colitis and to compare the …
