Effector mechanism of experimental autoimmune sialadenitis in the mouse model for primary Sjögren's syndrome

Y Hayashi, N Haneji, H Hamano, K Yanagi… - Cellular …, 1996 - Elsevier
We have recently established a new animal model for primary Sjögren's syndrome in
NFS/sld mutant mice thymectomized 3 days after birth (3dTX) bearing an autosomal
recessive gene with sublingual gland differentiation arrest. In this study, we analyze
developing mechanisms of experimental autoimmune sialadenitis (EAS) in the mouse
model, focusing on local expressions of cytokine and cell adhesion molecule genes by
reverse transcriptase–polymeric chain reaction (RT–PCR) and immunohistochemistry …