[HTML][HTML] Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells
M Jo, DB Stolz, JE Esplen, K Dorko… - Journal of Biological …, 2000 - ASBMB
In rat liver epithelial cells constitutively expressing transforming growth factor α (TGFα), c-
Met is constitutively phosphorylated in the absence of its ligand, hepatocyte growth factor.
We proposed that TGFα and the autocrine activation of its receptor, epidermal growth factor
receptor (EGFR), leads to phosphorylation and activation of c-Met. We found that there is
constitutive c-Met phosphorylation in human hepatoma cell lines and the human epidermoid
carcinoma cell line, A431 which express TGFα, but not in normal human hepatocytes …
Met is constitutively phosphorylated in the absence of its ligand, hepatocyte growth factor.
We proposed that TGFα and the autocrine activation of its receptor, epidermal growth factor
receptor (EGFR), leads to phosphorylation and activation of c-Met. We found that there is
constitutive c-Met phosphorylation in human hepatoma cell lines and the human epidermoid
carcinoma cell line, A431 which express TGFα, but not in normal human hepatocytes …
