[HTML][HTML] Impaired thrombin generation in β2-glycoprotein I null mice
Y Sheng, SW Reddel, H Herzog, YX Wang… - Journal of Biological …, 2001 - ASBMB
Autoimmune antibodies to β 2-glycoprotein I (β2GPI) have been proposed to be clinically
relevant because of their strong association with thrombosis, miscarriage, and
thrombocytopenia. By using a homologous recombination approach, β2GPI-null mice were
generated to begin to understand the physiologic and pathologic role of this prominent
plasma protein in mammals. When β2GPI heterozygotes on a 129/Sv/C57BL/6 mixed
genetic background were intercrossed, only 8.9% of the resulting 336 offspring possessed …
relevant because of their strong association with thrombosis, miscarriage, and
thrombocytopenia. By using a homologous recombination approach, β2GPI-null mice were
generated to begin to understand the physiologic and pathologic role of this prominent
plasma protein in mammals. When β2GPI heterozygotes on a 129/Sv/C57BL/6 mixed
genetic background were intercrossed, only 8.9% of the resulting 336 offspring possessed …