[HTML][HTML] A selective ε-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death
MO Gray, JS Karliner, D Mochly-Rosen - Journal of Biological Chemistry, 1997 - ASBMB
Protein kinase C activation is thought to protect cardiac tissue from subsequent ischemic
injury by a process termed preconditioning. The protein kinase C isozyme that mediates
preconditioning has not yet been identified. Using a cell culture model of hypoxic
preconditioning, we found that cardiac myocyte viability after 9 h of hypoxia was increased
by more than 50% over control. Preconditioning activated protein kinase C isozymes as
evidenced by translocation from one cell compartment to another as follows: there was a 2.1 …
injury by a process termed preconditioning. The protein kinase C isozyme that mediates
preconditioning has not yet been identified. Using a cell culture model of hypoxic
preconditioning, we found that cardiac myocyte viability after 9 h of hypoxia was increased
by more than 50% over control. Preconditioning activated protein kinase C isozymes as
evidenced by translocation from one cell compartment to another as follows: there was a 2.1 …
