Genetic regulation of the development of glomerular sclerotic lesions in the BUF/Mna rat
M Matsuyama, T Ogiu, K Kontani, C Yamada, M Kawai… - Nephron, 1990 - karger.com
M Matsuyama, T Ogiu, K Kontani, C Yamada, M Kawai, H Hiai, T Nakamura, F Shimizu…
Nephron, 1990•karger.comBUF/Mna strain rats spontaneously develop renal glomerular sclerotic lesions (RSL) at a
nearly 100% incidence, diagnosed by hyperalbuminuria (> 500 mg/dl) and glomerular
lesions morphologically resembling one type of human focal glomerular sclerosis (FGS).
Genetic segregation of RSL development was studied by crossing the BUF/Mna strain with
two other rat strains, WKY/NCrj and ACI/NMs, which were free of RSL. Two autosomal
recessive genes in the BUF/Mna rats were found to determine the susceptibility to RSL in …
nearly 100% incidence, diagnosed by hyperalbuminuria (> 500 mg/dl) and glomerular
lesions morphologically resembling one type of human focal glomerular sclerosis (FGS).
Genetic segregation of RSL development was studied by crossing the BUF/Mna strain with
two other rat strains, WKY/NCrj and ACI/NMs, which were free of RSL. Two autosomal
recessive genes in the BUF/Mna rats were found to determine the susceptibility to RSL in …
Abstract
BUF/Mna strain rats spontaneously develop renal glomerular sclerotic lesions (RSL) at a nearly 100% incidence, diagnosed by hyperalbuminuria ( > 500 mg/dl) and glomerular lesions morphologically resembling one type of human focal glomerular sclerosis (FGS). Genetic segregation of RSL development was studied by crossing the BUF/Mna strain with two other rat strains, WKY/NCrj and ACI/NMs, which were free of RSL. Two autosomal recessive genes in the BUF/Mna rats were found to determine the susceptibility to RSL in both combinations of crosses.
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